## Abstract To circumvent the cardiac toxicity of highβdose cyclophosphamide (CY) in the myeloablative conditioning for those with cardiac comorbidity, we developed a new cardiac sparing conditioning regimen (VP/rCY/TBI) composed of 12 Gy of total body irradiation (TBI), etoposide (VPβ16) (40 mg/kg
β¦ LIBER β¦
Etoposide in combination with cyclophosphamide and total body irradiation or busulfan as conditioning for marrow transplantation in adults and children
β Scribed by Thomas R. Spitzer; Christina Peters; Maureen Ortlieb; Mariella C. Tefft; John Torrisi; Richard Cahill; Helmut Gadner; Christian Urban; H.Joachim Deeg
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 857 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0360-3016
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## Abstract Twenty children with acute leukemia between 3 and 19 years of age underwent allogeneic bone marrow transplantation from HLAβmatched sibling donors after conditioning with totalβbody irradiation (1,200 cGy in six fractions of 200 cGy twice daily for 3 days) and high dose cytosine arabino