Etoposide, ifosfamide, and cisplatin therapy for refractory childhood solid tumors. Response and toxicity
β Scribed by Jack van Hoff; Holcombe E. Grier; Edwin C. Douglass; Daniel M. Green
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 416 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. Approximately 30% of patients with metastatic germ cell tumors require salvage chemotherapy for recurrent or refractory disease after first-line treatment. The optimal salvage chemotherapy regimen remains to be determined. ## METHODS. Fifty-four patients with metastatic germ cell
A prospective study of four cycles of etoposide with ifosfamide and cisplatin (VIP) chemotherapy was conducted in 42 germ cell tumor (GCT) patients who were refractory to cisplatin with etoposide/vinblastine-based therapy. Forty patients were evaluable for response. Ten patients (25%) had a complete