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Etirinotecan Pegol: Development of a Novel Conjugated Topoisomerase I Inhibitor

✍ Scribed by Alemany, Carlos

Book ID
125376072
Publisher
Current Science Inc.
Year
2014
Tongue
English
Weight
156 KB
Volume
16
Category
Article
ISSN
1523-3790

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## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (ο£ΏCH~2~ο£Ώ) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its acti