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EthylN-(diphenylmethylene)glycinate as anionic glycine equivalent transition metal mediated preparation of bicyclic and tricyclic α,α-disubstituted α-amino acids and derivatives

✍ Scribed by Moreno-Mañas, Marcial ;Pleixats, Roser ;Roglans, Anna

Book ID: 102904212
Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 989 KB
Volume: 1995
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.1995199510253

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✦ Synopsis

Abstract

Synthetic approaches to bicyclic and tricyclic α,α‐disubstituted α‐amino acids and derivatives 6, 8, 10, 12, 13, 21, 22, 23, 24, 28, 30, and 31 are presented. Methyl acetoacetate, ethyl nitroacetate, and ethyl N‐(diphenylmethylene)glycinate are compared as anionic glycine equivalents. Palladium‐induced reductive couplings, Diels‐Alder and Pauson‐Khand reactions are used in the cyclisation steps.

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