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Ethnic Variation in Allele Distribution of the Androgen Receptor (AR) (CAG)n Repeat

✍ Scribed by Ackerman, C. M.; Lowe, L. P.; Lee, H.; Hayes, M. G.; Dyer, A. R.; Metzger, B. E.; Lowe, W. L.; Urbanek, M.

Book ID
119924892
Publisher
American Society of Andrology
Year
2011
Tongue
English
Weight
208 KB
Volume
33
Category
Article
ISSN
1939-4640

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The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repeat codifies for a polyglycine tract, and affects th