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Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes

✍ Scribed by Marie-Anne Robin; Ingrid Sauvage; Thomas Grandperret; Véronique Descatoire; Dominique Pessayre; Bernard Fromenty

Book ID
116466192
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
368 KB
Volume
579
Category
Article
ISSN
0014-5793

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The release of proinflammatory cytokines by endotoxins and during oxidative stress is considered to be an early key step in the pathogenesis of alcoholic liver disease (ALD). Ethanol-inducible cytochrome P450 2E1 (CYP2E1) has potentially pro-oxidative and toxicological properties, and its expression