Ethanol, Acetaldehyde and Cardiac Protein Synthesis: the relation to cardiomyopathy
β Scribed by SIDNEY S. SCHREIBER
- Book ID
- 108593418
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 605 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0965-2140
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## Abstract We have determined the extent to which acute ethanol administration perturbs the synthesis of ventricular contractile and nonβcontractile proteins __in vivo__. Male Wistar rats were treated with a standard dose of ethanol (75 mmol kg^β1^ body weight; i.p.). Controls were treated with is
and generate hybrid adducts (MAA-adducts) and further Acetaldehyde and the lipid peroxidation-derived aldesuggest that MAA adducts may represent a major species hyde malondialdehyde (MDA), are reactive compounds of adducts formed in the liver during ethanol metabothat are generated during ethanol me
With the aid of a kinetic model, we have investigated how the adaptation between the various components of the tRNA cycle and the codon frequencies affects the rate of protein synthesis. Depending on the relative amounts of total tRNA, synthetase and ribosomes, the optimal correlations vary between