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Ethacrynic acid as a lead structure for the development of potent urease inhibitors

✍ Scribed by Janser, Ingo; Vortolomei, Caitlyn M.; Meka, Ranjith K.; Walsh, Courtney A.; Janser, Romy F.J.


Book ID
122577323
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
338 KB
Volume
16
Category
Article
ISSN
1631-0748

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A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group, and by extending the acetic acid side chain. These compounds show anti-inflammatory activity in rats with no evidence of GI toxicity, even