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A New Structural Motif for the Design of Potent Glucosidase Inhibitors

✍ Scribed by Tanaka, Kelly S. E.; Winters, Geoffrey C.; Batchelor, Raymond J.; Einstein, Frederick W. B.; Bennet, Andrew J.


Book ID
118134353
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
44 KB
Volume
123
Category
Article
ISSN
0002-7863

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✍ Venerando Pistarà; Antonio Rescifina; Francesco Punzo; Graziella Greco; Vincenzi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 852 KB

## Abstract This work deals with the design and synthesis of α‐glucosidase inhibitors. In order to perform this task, a molecular docking study was carried out with the __N__‐terminal catalytic subunit of human maltase glucoamylase, which evidenced a partially empty, hydrophobic part of the docking