## Abstract __O__^6^‐alkylguanine‐DNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of __O__^6^‐alkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobacco‐spe
✦ LIBER ✦
Estrous cycle modulation of O6-alkylguanine-DNA alkyltransferase expression in rat mammary epithelial cells
✍ Scribed by Chang, Bey-Dih; Beattie, Craig W.; Hussain, Raouf A.; Anderson, Conwell H.
- Book ID
- 122858310
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 876 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0304-3835
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## Abstract O^6^‐Alkylguanine is a major toxic, mutagenic, and carcinogenic lesion in cellular DNA that is repaired by O^6^‐alkylguanine‐DNA alkyltransferase (ATase). The expression of this gene is directly related to the cellular sensitivity of alkylating agents, with levels of this protein varyin