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Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia

✍ Scribed by Volker Vielhauer; Marina Sarafoff; Peter Gais; Hartmut M. Rabes

Book ID
106124912
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
691 KB
Volume
127
Category
Article
ISSN
1432-1335

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## Abstract O^6^‐Alkylguanine is a major toxic, mutagenic, and carcinogenic lesion in cellular DNA that is repaired by O^6^‐alkylguanine‐DNA alkyltransferase (ATase). The expression of this gene is directly related to the cellular sensitivity of alkylating agents, with levels of this protein varyin