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Estrogens and antiestrogens activate hPXR

✍ Scribed by Wissem Mnif; Jean-Marc Pascussi; Arnaud Pillon; Aurélie Escande; Aghleb Bartegi; Jean-Claude Nicolas; Vincent Cavaillès; Marie-Josèphe Duchesne; Patrick Balaguer

Book ID
119379117
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
768 KB
Volume
170
Category
Article
ISSN
0378-4274

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The classical estrogen receptor model does not suficiently account for the tumor-promoting acticity of extrogens or for the antiprolferative effect of antiestrogens in estrogen-dependent tumors. Particular dificulties not readily arcommodated within the model are that hormonal autonomy can supervene