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Estrogens, antiestrogens and cell proliferation

✍ Scribed by Oi Lian Kon

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
744 KB
Volume
10
Category
Article
ISSN
0265-9247

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✦ Synopsis

The classical estrogen receptor model does not suficiently account for the tumor-promoting acticity of extrogens or for the antiprolferative effect of antiestrogens in estrogen-dependent tumors. Particular dificulties not readily arcommodated within the model are that hormonal autonomy can supervene without loss of' the estrogen receptor and that antiestrogen effects are highly contextdependent, without apparent diflerences in the estrogen receptor itself or in metabolic transformation of antiestrogens. Recent studies suggest that estrogens may promote cell prolijeration, in part, through the mediation of growth factors and thut antiestrogens may exert some of their efects by mechanisms unrelated to the estrogen receptor.

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