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Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

โœ Scribed by Ann-Charlotte E Granholm; Kerstin A Ford; Lynn A Hyde; Heather A Bimonte; Christopher L Hunter; Matt Nelson; David Albeck; Linda A Sanders; Elliott J Mufson; Linda S Crnic

Book ID
117197861
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
381 KB
Volume
77
Category
Article
ISSN
0031-9384

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## Abstract Individuals with Down syndrome (DS) develop the pathological hallmarks of Alzheimer's disease at an early age, later followed by memory decline and dementia. Women with DS are twice as likely to undergo early menopause, and levels of estradiol correlate with onset of cognitive decline i