This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (>3 fmoUmg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to
Estrogen receptor α gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients
✍ Scribed by Saori Tomita; Zhenhuan Zhang; Masahiro Nakano; Mutsuko Ibusuki; Teru Kawazoe; Yutaka Yamamoto; Hirotaka Iwase
- Book ID
- 108586430
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 827 KB
- Volume
- 100
- Category
- Article
- ISSN
- 1347-9032
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Estrogen (ER) and progesterone (PgR) receptors were assayed by histochemistry in primary, recurrent, and metastatic breast cancer. Ligand-conjugates composed of 17P-estradiol and 1 lcu-hydroxyprogesterone covalently linked to bovine serum albumin and labelled with fluorescein isothiocyanate were emp
## BACKGROUND. Historically, estrogen receptor (ER) determinations have been made by the ligand-binding assay of tumor homogenates, primarily by the dextrancoated charcoal method (DCC). Irnrnunocytochernical assays (ICA) for ER are more recent and have been executed mostly on frozen sections with t