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Estrogen receptor- , RBCK1, and protein kinase C 1 cooperate to regulate estrogen receptor- gene expression

✍ Scribed by Gustafsson Sheppard, N.; Heldring, N.; Dahlman-Wright, K.

Book ID
118135536
Publisher
Bioscientifica
Year
2012
Tongue
English
Weight
239 KB
Volume
49
Category
Article
ISSN
0952-5041

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✍ Soma Mandal; James R. Davie πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept