Estrogen receptor protein (ERP) in multiple tumor specimens from individual patients with breast cancer
β Scribed by Paul Peter Rosen; Celia J. Menendez-Botet; Jerome A. Urban; Alfred Fracchia; Morton K. Schwartz
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 565 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0008-543X
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A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER Ψ tum
## Abstract The relative ability of the antiestrogen, tamoxifen, and its monohydroxy and desmethyl metabolites to displace tritiated estradiol from estrogen receptors isolated from human breast carcinoma was determined. 4βHydroxytamoxifen binds to the estrogen receptor with affinity equal to estrad