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Estrogen-insulin synergism in induction of prolactin in growth hormone-producing cells

โœ Scribed by Nagata, S.; Inoue, K.; Senshu, T.


Book ID
121817603
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
664 KB
Volume
82
Category
Article
ISSN
0303-7207

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Increased peptidylarginine deiminase exp
โœ Saburo Nagata; Takemi Uehara; Kinji Inoue; Tatsuo Senshu ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 838 KB

Insulin and type I insulin-like growth factor (IGF-I) suppressed growth hormone (GH) expression followed by the induction of prolactin (PRL) biosynthesis in MtT/S cells cultured with normal sera. Insulin also increased the peptidylarginine deiminase activity in a dose-dependent manner. The increase