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Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal

✍ Scribed by J.S. Lewis; C. Osipo; K. Meeke; V.C. Jordan

Book ID: 116697534
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 350 KB
Volume: 94
Category: Article
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2004.12.032

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## Abstract Overexpression of Her2/neu is implicated in the development of resistance to the antiestrogen tamoxifen (TAM) that exerts its inhibitory effect through interaction with estrogen receptor (ER). Whereas Her2/neu and ER are believed to be important cell survival/death factors in human brea