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Adaptive mechanisms induced by long-term estrogen deprivation in breast cancer cells

✍ Scribed by R.X Song; R.J Santen; R Kumar; L Adam; M.-H Jeng; S Masamura; W Yue


Book ID
117463081
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
535 KB
Volume
193
Category
Article
ISSN
0303-7207

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In an attempt to understand the mechanism by which estrogens stimulate cell proliferation and mammary carcinogenesis, metastatic human breast cancer cell lines (MCF7, ZR75-1) were found to secrete a 52,000 dalton (52K) protein under estrogen stimulation. Following its purification to homogeneity, th