This report describes an investigation of the role of 1,25-dihydroxyvitamin D (VD 3 ) in the regulation of estrogen receptor-β£ (ER) in the ER-positive breast cancer cell line, MCF-7. Treatment of cells with 10 nM VD 3 resulted in a 50% decline in the concentration of ER protein at 24 h. Scatchard an
Estrogen controls expression and bioresponse of 1,25-dihydroxyvitamin D receptors in the rat colon
β Scribed by Betty Schwartz; Patricia Smirnoff; Shraga Shany; Yair Liel
- Book ID
- 110246310
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 81 KB
- Volume
- 203
- Category
- Article
- ISSN
- 0300-8177
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The present study investigates the presence of vitamin D receptor (VDR) in cells of the rat oligodendrocyte (OL) lineage. VDR transcripts were detected by in situ hybridization in a fraction of rat OL in secondary cultures. The VDR protein was shown to be co-localized in cells that are also recogniz
Differentiation and proliferation can be regulated in diverse cell types by 1,25-dihydroxyvitamin D 3 . These effects derive from modulation of gene expression mediated by the interaction of 1,25-dihydroxyvitamin D 3 with the vitamin D receptor (VDR). The VDR is one of the nuclear hormone receptors.