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1,25-Dihydroxyvitamin D3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats

✍ Scribed by Denda, Masashi; Finch, Jane; Brown, Alex J; Nishii, Yasuho; Kubodera, Noboru; Slatopolsky, Eduardo


Book ID
109884485
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
620 KB
Volume
50
Category
Article
ISSN
0085-2538

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Recently, 1,25-dihydroxyvitamin D 3 (1,25-D 3 ) and less hypercalcemic analogs were shown to exert a delayed cytotoxic effect on rat C6 glioma cells. 1,25-D 3 induces in these cells a programmed cell death, accompanied by the induction of c-myc, p53 and gadd 45 genes. The involvement of the intracel