✦ LIBER ✦

Estrogen concentration by substance p-immunoreactive neurons in the medial basal hypothalamus of the female rat

✍ Scribed by Dr. T. R. Akesson; P. E. Micevych

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 794 KB
Volume: 19
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490190405

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✦ Synopsis

We used the combined technique of steroid autoradiography and immunohistochemistry to simultaneously visualize estrogen-concentrating and substance P-immunoreactive (sP-IR) cells. A substantial proportion (26.1%) of sP-IR cells that bound estrogen was found in the anterior two thirds of the arcuate nucleus with a rapidly diminishing number of cases (8.7%) in the posterior extent of this nucleus. Highest proportions (42.9%) of sP-IR cells retaining estrogen were found in the ventrolateral part of the ventromedial hypothalamic nucleus. The ventral premammillary nucleus was observed to have both populations but coexistence was comparatively infrequent (2.4%). Occasional cases of coexistence were also found in the lateral hypothalamic area. These results provide anatomical evidence that a subset of sP-IR neurons are directly regulated by estrogen and support the hypothesis that sP-containing cells participate in the transduction of hormonal information into a CNS circuitry that regulates gonadotropin secretion and sexual behavior.

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