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Estrogen Carcinogenesis in Breast Cancer

✍ Scribed by Germain, Doris

Book ID
121906184
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
104 KB
Volume
40
Category
Article
ISSN
0889-8529

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In an attempt to understand the mechanism by which estrogens stimulate cell proliferation and mammary carcinogenesis, metastatic human breast cancer cell lines (MCF7, ZR75-1) were found to secrete a 52,000 dalton (52K) protein under estrogen stimulation. Following its purification to homogeneity, th