The replication of several human and animal cancer cell lines is regulated in vitro and in vivo by 1,25-dihydroxyvitamin D3 I 1 ,25-(OH),D3], the hormonally active form of vitamin Uj. We have examined the effects of concentrations of 1 ,25-(OH)2D3, which inhibit cellular replication, on the cell-cyc
Estrogen and rapamycin effects on cell cycle progression in T47D breast cancer cells
โ Scribed by Haiyan Pang; Lee E. Faber
- Book ID
- 110314418
- Publisher
- Springer US
- Year
- 2001
- Tongue
- English
- Weight
- 157 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0167-6806
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๐ SIMILAR VOLUMES
T47D human breast cancer cells were cultured in estrogen-deficient media for up to 32 months and the resulting cell line (L(hE(-))) exhibited unique phenotypic and genotypic characteristics. Compared to low passage (L) cells, the L(hE(-)) cells exhibited a significantly higher rate of proliferation,
When deprived of steroid in the long term, T-47-D human breast cancer cells lose estrogen sensitivity of cell growth. This loss of response results from an increased basal growth rate in the absence of steroid, not from a loss of estrogen-stimulated growth, and it occurs without any loss of estrogen