Estrogen and Progesterone Receptors in Gastric Cancer

✍ Scribed by Akira Tokunaga; Keigo Nishi; Norio Matsukura; Noritake Tanaka; Masahiko Onda; Akiro Shirota; Goro Asano; Kazuo Hayashi

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 401 KB
• Volume: 57
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19860401)57:7<1376::aid-cncr2820570722>3.0.co;2-z

✦ Synopsis

Cancerous tissue from 86 patients with primary gastric cancer were examined for the presence of receptors for estrogen (ER) and progesterone (PgR). ER and PgR were present in 8 (15.4%) and 5 (9.6%), respectively, of 52 male patients, 9 (26.6%) and 7 (20.6%), respectively, of 34 female patients, a total of 17 (19.8%) and 12 (14.0%), respectively. One male patient (1.9%) and 4 female patients (11.8%) had both ER and PgR, and 40 male (76.9%) and 22 female patients (64.7%) showed no ER or PgR. The binding activity ranged from 6 to 200 fmol/mg protein for estradiol and from 5 to 58 fmol/mg protein for progesterone. ER-and/or PgR-positive cases were characterized grossly as Borrmann type 4, and microscopically as diffuse type with scirrhous growth pattern. The presence of ER and/or PgR in some gastric cancers indicates the possibility that sex hormonal factors are involved in these tumors.