Estimation of the effective intercellular diffusion coefficient in cell monolayers coupled by gap junctions
โ Scribed by Niels Erik Olesen; Johannes P. Hofgaard; Niels-Henrik Holstein-Rathlou; Morten Schak Nielsen; Jens Christian Brings Jacobsen
- Book ID
- 113592506
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 758 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0928-0987
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๐ SIMILAR VOLUMES
A general model for the transfer of ions and molecules between two cells via a gap junction is presented. This constitutes a dynamical system consisting of two connected parts: the dynamics of intracellular concentrations and electrical potentials, and the dynamics of the gating in the gap junction.
We have previously shown that gap-junctional intercellular communication (GJIC) appears to play a role in the bystander effect that is observed in anticancer suicide gene therapy mediated by herpes simplex virus (HSV) thymidine kinase (tk) and ganciclovir (GCV). We now report that when connexin-expr