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Estimation of the direct and indirect effects of vaccination

โœ Scribed by Michael Haber

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
92 KB
Volume
18
Category
Article
ISSN
0277-6715

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โœฆ Synopsis

Indirect e!ects play a major role in the protection a!orded by a vaccination programme. In this work we de"ne new measures of direct, indirect and total (direct#indirect) e!ects of a vaccination programme in terms of the protection they provide to unvaccinated and vaccinated individuals, and to the entire population. We show how these measures can be estimated using data from a vaccine trial or an observational study. The bias and standard errors of these estimates can be evaluated via stochastic simulations. Examples from a mumps outbreak and a (hypothetical) HIV vaccine trial are used to illustrate the estimation of these new measures of vaccination e!ectiveness.

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