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Estimation of nitrogen-15 levels in derivatized amino acids using gas chromatography quadrupole mass spectrometry with chemical ionization and selected ion monitoring

✍ Scribed by J. R. Robinson; A. N. Starratt; E. E. Schlahetka

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 634 KB
Volume: 5
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200051203

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✦ Synopsis

The data indicate that a commercial, low resolution mass spectrometer can be used with chemical ionization and selected ion monitoring, without a data system, to estimate nitrogen-15 isotopic enrichment with a sensitivity and precision adequate for many biological studids. This was demonstrated using derivatized qmino acid mixtures with separation and direct introduction into the mass Spectrometer via a gas chromatograph. The method can discriminate between mean levels separated by 0.1 atom '/o "N with 68% confidence at the 0.1 nmol level.

Labeled dansyl amide samples, inserted by probe, were also measured for "N content.

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