✦ LIBER ✦

Determination of clonazepam and its amino and acetamido metabolites in human plasma by combined gas chromatography chemical ionization mass spectrometry and selected ion monitoring

✍ Scribed by B. H. Min; W. A. Garland; K.-C. Khoo; G. S. Torres

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 702 KB
Volume: 5
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200051211

No coin nor oath required. For personal study only.

✦ Synopsis

Our previously published gas chromatography chemical ionization mass spectrometry stable isotope dilution assay for clonazepam and its 7-amino metabolite in plasma has been modified to obtain more consistent recoveries of the amine metabolite and to permit the determination of the 7-acetamido metabolite of clonazepam. In addition, the manuscript describes the details of a method for a least squares analysis of the nonlinear standard curves associated with the use of certain stable isotope labeled analogs as internal standard.

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