Estimation of multiple biomass growth rates and biomass concentration in a class of bioprocesses
β Scribed by V. Lubenova; I. Rocha; E. C. Ferreira
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 496 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1615-7605
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In this study, previously developed five different state estimation methods are examined and compared for estimation of biomass concentrations at a production scale fed-batch bioprocess. These methods are i. estimation based on kinetic model of overflow metabolism; ii. estimation based on metabolic
## Abstract This article describes a novel bioreactor configuration for production optimization of recombinant proteins in __Escherichia coli__. Inducer addition and harvesting are controlled onβline based on indirect estimation of biomass concentration and specific growth rate from addition of NaO