Estimation and Confidence Regions for Multi-Dimensional Effective Dose
β Scribed by Jialiang Li; Erik V. Nordheim; Chunming Zhang; Charles E. Lehner
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 175 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0323-3847
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
An important issue in dose finding is whether a further dose increment leads to a relevant increase in efficacy. Clinical efficacy should not be considered by point zero null hypotheses. Instead, shifted hypotheses for the difference or the ratio can be used. Because the a priori definition of a rel
## Abstract Parametric bootstrap methods for the construction of confidence intervals for the effective dose at level Ξ±(EDΞ±) under the probit model for the doseβresponse relationship are investigated. The standard maximum likelihood confidence intervals and percentile, centered percentile, studenti
Boundary element methods (BEM) have been implemented for solving multi-region elastoplastic problems with the maximum efficiency. A new form of Newton-Raphson algorithm in nonlinear BEM is established in which the formation of the right hand side terms in each iteration is accurately represented. In
In Britain wheat is an important crop accounting for 41% of the total cereal production. In this study ozone concentrations for 1989 estimated as described in Part 1 of the paper are integrated with the estimated wheat distribution to derive a detailed estimate of the impact of ozone on wheat yields