## Human and Department of Genetics, Communicated by Victor A. McKwick We propose a method of measuring the human genomic deleterious mutation rate based on comparison of the rate of evolution per nucleotide per generation of neutral sequences, pN, with the overall rate of evolution of unique sequ
β¦ LIBER β¦
Estimating the human mutation rate using autozygosity in a founder population
β Scribed by Campbell, Catarina D; Chong, Jessica X; Malig, Maika; Ko, Arthur; Dumont, Beth L; Han, Lide; Vives, Laura; O'Roak, Brian J; Sudmant, Peter H; Shendure, Jay; Abney, Mark; Ober, Carole; Eichler, Evan E
- Book ID
- 115485400
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 696 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng.2418
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## Summary In a conservation programme with genealogical records it is possible to estimate the amount of variability of the founder population from a measure of the similarity among the individuals in the current population based on microsatellite markers. Here we compare three available methods a
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