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Establishment of embryonic stem cells secreting human factor VIII for cell-based treatment of hemophilia A

✍ Scribed by S. KASUDA; A. KUBO; Y. SAKURAI; S. IRION; K. OHASHI; K. TATSUMI; Y. NAKAJIMA; Y. SAITO; K. HATAKE; S. W. PIPE; M. SHIMA; A. YOSHIOKA

Book ID
109152580
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
276 KB
Volume
6
Category
Article
ISSN
1538-7933

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Functional aspects of factor VIII expres
Functional aspects of factor VIII expression after transplantation of genetically-modified hematopoietic stem cells for hemophilia A
✍ Lucienne M. Ide; Neal N. Iwakoshi; Bagirath Gangadharan; Shawn Jobe; Robert Moot πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 475 KB

## Abstract ## Background Major complications with respect to the development of gene therapy treatments for hemophilia A include low factor VIII (fVIII) expression and humoral immune responses resulting in inhibitory anti‐fVIII antibodies. We previously achieved sustained curative fVIII activity