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Establishment and functional validation of a structural homology model for human DNA methyltransferase 1

✍ Scribed by Pawel Siedlecki; Regine Garcia Boy; Slobodan Comagic; Ralf Schirrmacher; Manfred Wiessler; Piotr Zielenkiewicz; Sandor Suhai; Frank Lyko


Book ID
117054083
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
364 KB
Volume
306
Category
Article
ISSN
0006-291X

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Human serum paraoxonase (HuPON1) is a calcium-dependent enzyme that hydrolyzes esters, including organophosphates and lactones, and exhibits anti-atherogenic properties. A few amino acids have been shown to be essential for the enzyme's arylesterase and organophosphatase activities. Until very recen