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Establishing a protein-protein interaction networks for hypertrophic cardiomyopathy

✍ Scribed by Chia-Chun Lu; Ching-Shiun Chang; Ming-Ju Tsai; Yu-Shan Chen; Yueh Chen; Ing-Fang Yang; Ten-Fang Yang


Book ID
113702240
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
259 KB
Volume
44
Category
Article
ISSN
1532-8430

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In this paper, we study spectral clustering for detecting protein complexes in PPI (protein-protein interaction) networks, focusing on two open issues: (i) constructing similarity graphs; and (ii) determining the number of clusters. First, we study four similarity graphs to construct graph Laplacian