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Computational approaches for detecting protein complexes from protein interaction networks: a survey

✍ Scribed by Xiaoli Li; Min Wu; Chee-Keong Kwoh; See-Kiong Ng

Book ID
115003491
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
621 KB
Volume
11
Category
Article
ISSN
1471-2164

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Spectral clustering for detecting protei
Spectral clustering for detecting protein complexes in protein–protein interaction (PPI) networks
✍ Guimin Qin; Lin Gao πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 416 KB

In this paper, we study spectral clustering for detecting protein complexes in PPI (protein-protein interaction) networks, focusing on two open issues: (i) constructing similarity graphs; and (ii) determining the number of clusters. First, we study four similarity graphs to construct graph Laplacian