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Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice

✍ Scribed by Yi Zhang; Hui Li; Yi Li; Xiuli Sun; Mengyang Zhu; Gregory Hanley; Gene LeSage; Deling Yin


Book ID
116772818
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
371 KB
Volume
489
Category
Article
ISSN
0304-3940

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## Abstract Microglia are activated by lipopolysaccharide (LPS) to produce neurotoxic pro‐inflammatory factors and reactive oxygen species (ROS). While a multitude of LPS receptors and corresponding pathways have been identified, the detailed mechanisms mediating the microglial response to LPS are