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Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation

✍ Scribed by Nathalie Busso, Veronique Chobaz-Péclat, Justin Hamilton…

Book ID
120706637
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
1003 KB
Volume
10
Category
Article
ISSN
1478-6354

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## Background: Cathepsin g (cat-g) is a neutrophil serine-protease found in the colonic lumen of ulcerative colitis (uc) patients. cat-g is able to activate protease-activated receptor-4 (par(4) ) located at the apical side of enterocytes, leading to epithelial barrier disruption. however, the mech