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S1649 Intracolonic Infusion of Fecal Supernatant from UC Patients Triggers Altered Permeability and Inflammation in Mice: Role of Cathepsin G and Protease-Activated Receptor-4

✍ Scribed by Dabek, Marta; Ferrier, Laurent; Annahazi, Anita; Róka, Richárd; Gecse, Krisztina; Wittmann, Tibor; Fioramonti, Jean; Theodorou, Vassilia; Bueno, Lionel

Book ID: 122656285
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 78 KB
Volume: 136
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(09)61095-7

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Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4

✍ Marta Dabek; Laurent Ferrier; Anita Annahazi; Valérie Bézirard; Arnaud Polizzi; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 579 KB

## Background: Cathepsin g (cat-g) is a neutrophil serine-protease found in the colonic lumen of ulcerative colitis (uc) patients. cat-g is able to activate protease-activated receptor-4 (par(4) ) located at the apical side of enterocytes, leading to epithelial barrier disruption. however, the mech