✍ Scribed by Luca Baumer; Ilaria Compagnari; Giordano Sala; Guido Sello
No coin nor oath required. For personal study only.
Computer‐Assisted Organic Synthesis (CAOS) has become a common tool in synthesis pathway design. Many different approaches exist, each giving suggestions for the exploration of the synthetic space. Validation of the proposed solutions can be done both by using different programs and by experimental realization of the synthesis. To this end, a molecule of medium complexity, erythronolide B, has been used to make a three‐way comparison using results obtained by the program LHASA, in the laboratory, and by the program Lilith. The importance of using different sources in studying a synthesis pathway is discussed, with respect to achieving the best result from each approach. The high level of convergence in the syntheses proposed by the Lilith program is the most interesting characteristic of the program's results. Moreover, reproduction of the syntheses proposed by the other approaches guarantees the applicability of the Lilith program to real synthetic problems. A brief outline of the Lilith program is included.
📜 SIMILAR VOLUMES
## Abstract Two stereoisomers (1a and 1b) of __N__‐(L‐valyl)‐2′,5‐dihydroxyhomoproline, the proposed structure of the dipeptide antibiotic Tü 1718 B, were synthesized by starting from natural (2__S__,4__R__)‐hydroxyproline. The ^1^H‐ and ^13^C‐NMR spectra of 1a and 1b clearly differ from the corres