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Erythrocyte lithium–sodium countertransport and total body lithium pharmacokinetics in patients with affective illness

✍ Scribed by Janusz Rybakowski; Wenancja Lehmann; Roman Kanarkowski

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
475 KB
Volume
3
Category
Article
ISSN
0885-6222

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✦ Synopsis

Previous studies suggested that in patients with affective illness, lithium ion accumulated more in erythrocytes (higher erythrocyte lithium ratio) as well as in the total body (greater lithium retention). The aim of this study was to estimate the relationship between erythrocyte lithium transport mechanisms and the parameters of lithium pharmacokinetics in 11 affective patients during depressive episodes. It was found that the activity of erythrocyte lithium-sodium countertransport (LSC) governing lithium transport out of the erythrocytes, measured in vitro, significantly correlated with rate constant (K21) of lithium transport from intra-to extracellular compartment. Passive lithium diffusion (PLD) in erythrocytes correlated with K21/ K12 ratio. Neither LSC nor PLD correlated with renal lithium clearance. The results show that, in affective patients, the activity of erythrocyte LSC may serve as a model of the intensity of lithium extrusion from cells in the total body.

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