Erythroblastic transformation of chronic granulocytic leukemia
β Scribed by Invernizzi, R. ;Balduini, C. L. ;Ricevuti, G. ;Rizzo, S. C.
- Publisher
- Springer-Verlag
- Year
- 1982
- Weight
- 428 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1432-0584
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Three cases of megakaryoblastic transformation of chronic granulocytic leukemia (CGL) are reported. In each case, the leukemic transformation had morphologic features suggesting megakaryocytic differentiation. This was confirmed by positive immunostaining with a monoclonal antibody (HP1-1D) specific
The requirements of erythropoiesis for erythropoietin were studied in a patient with Ph' chronic myelocytic leukemia who had undergone an erythroblastic transformation. Transfusions resulted in a suppression of erythropoiesis. Plasma clot culture studies indicated that both the CFU-E and BFU-E in th