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Erratum: Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis


Book ID
109912129
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
47 KB
Volume
6
Category
Article
ISSN
1465-7392

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The binding of many ligands to cellular receptors induces a signaling cascade which generates inositol 1,4,5-trisphosphate (IP 3 ). IP 3 binding to its receptors in various internal compartments causes a rapid Ca 21 efflux into the cytosol. We now demonstrate that chloroquine blocks ligand-induced C