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Inositol 1,4,5-trisphosphate Binds to a Specific Receptor and Releases Microsomal Calcium in the Anterior Pituitary Gland

✍ Scribed by Gaetan Guillemette, Tamas Balla, Albert J. Baukal and Kevin J. Catt


Book ID
123634818
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
856 KB
Volume
84
Category
Article
ISSN
0027-8424

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The binding of many ligands to cellular receptors induces a signaling cascade which generates inositol 1,4,5-trisphosphate (IP 3 ). IP 3 binding to its receptors in various internal compartments causes a rapid Ca 21 efflux into the cytosol. We now demonstrate that chloroquine blocks ligand-induced C