Chloroquine, quinine and quinidine inhib
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Uma Kant Misra; Govind Gawdi; Salvatore V. Pizzo
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Article
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1997
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John Wiley and Sons
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English
β 110 KB
The binding of many ligands to cellular receptors induces a signaling cascade which generates inositol 1,4,5-trisphosphate (IP 3 ). IP 3 binding to its receptors in various internal compartments causes a rapid Ca 21 efflux into the cytosol. We now demonstrate that chloroquine blocks ligand-induced C