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Erlotinib plus gemcitabine in patients with unresectable pancreatic cancer and other solid tumors: phase IB trial

✍ Scribed by Tomislav Dragovich; Mark Huberman; Daniel D. Von Hoff; Eric K. Rowinsky; Paul Nadler; Debra Wood; Marta Hamilton; George Hage; Julie Wolf; Amita Patnaik

Publisher
Springer
Year
2006
Tongue
English
Weight
310 KB
Volume
60
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi