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ERK, and its downstream target, est-1, are involved in the 1,25(OH)2D3-induced inhibition of cell growth and stimulation of apoptosis in Caco-2 cells

✍ Scribed by Chen, Anping; Bissonnette, Marc; Sitrin, Michael D.; Brasitus, Thomas A.


Book ID
124113814
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
182 KB
Volume
120
Category
Article
ISSN
0016-5085

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1alpha,25(OH)(2)D(3) regulates rat growth plate chondrocytes via nuclear vitamin D receptor (1,25-nVDR) and membrane VDR (1,25-mVDR) mechanisms. To assess the relationship between the receptors, we examined the membrane response to 1alpha,25(OH)(2)D(3) in costochondral cartilage cells from wild type