Ergotamine tartrate U.S.P.

✍ Scribed by G. L. Szendey

• Publisher: John Wiley and Sons
• Year: 1962
• Tongue: English
• Weight: 288 KB
• Volume: 51
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600510922

✦ Synopsis

On the basis of melting point and solubility, ergotamine tartrate U.S.P. is a mixture of ergotamine tartrate and ergotamine bitartrate. Several samples with different properties were studied by means of titrimetric methods in nonaqueous media using 0.05 N perchloric acid and 0.1 N potassium methoxide. T h e melting point well indicates the approximate ratio of ergotamine tartrate-bitartrate mixture. Er- gotamine tartrate with a melting point of about 180 a (decompn.) contains aboul83?<, ergotarnine base, equivalent to O4Yb ergotamine tartrate.

EVERAL authors reported (1-4) a discrepancy S concerning ergotamine tartrate U.S.P. It was stated that requirements for solubility and melting point represent, contrary to the British Pharmacopoeia, a mixture of ergotamine tartrate