ER-to-Golgi transport visualized in living cells
โ Scribed by Lippincott-Schwartz, Jennifer; Presley, John F.; Cole, Nelson B.; Schroer, Trina A.; Hirschberg, Koret; Zaal, Kristien J. M.
- Book ID
- 109795316
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 493 KB
- Volume
- 389
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/38001
No coin nor oath required. For personal study only.
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Pichia pastoris has discrete transitional ER sites and coherent Golgi stacks, making this yeast an ideal system for studying the organization of the early secretory pathway. To provide molecular tools for this endeavour, we isolated P. pastoris homologues of the SEC12, SEC13, SEC17, SEC18 and SAR1 g
Several complementary approaches have been fruitful in the study of transport from the ER to the Golgi complex in yeast. Mutational analysis has led to the identification of genes required for this process, many of which are now being studied at the molecular and biochemical level. In the case of SE