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Epstein-Barr virus-specific antibody titers in seven Alaskan Natives before and after diagnosis of nasopharyngeal carcinoma

✍ Scribed by Anne P. Lanier; Werner Henle; Thomas R. Bender; Gertrude Henle; Marion L. Talbot

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
431 KB
Volume
26
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Results are presented of Epstein‐Barr virus‐specific serologic tests for seven Alaskan Native patients with nasopharyngeal carcinoma (NPC) from whom serum had been collected 2–10 years before diagnosis and up to 6 years after diagnosis. The pre‐illness antibody spectra and titers of the NPC patients did not differ from those of controls. However, broadened antibody spectra and elevated titers were associated with the emergence of NPC disease, which in one case was present as early as 22 months before actual diagnosis. Increasing or continuously high antibody titers were associated with progression of the disease and death, whereas patients who maintained relatively low, stable antibody titers after treatment have remained well.

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